Week 15 of the 2024 fantasy football season begins with a Thursday night matchup between the Los Angeles Rams and San Francisco 49ers. This is a major NFC West matchup with playoff implications pitting two teams with powerful offenses against each other. Here are some of the best targets and fades for this week’s fantasy lineups.
Week 15 49ers vs Rams TNF Fantasy Football Start ‘Em Picks
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Kyren Williams is having an incredibly consistent 2024 fantasy football season, finishing as RB27 or better in his 13 games so far. He also finished in the top ten weekly running backs four times, including each of the last two weeks, leading to his current overall ranking as RB7 this year. He’s an elite lineup option this week against the San Francisco 49ers, despite facing a strong defense.
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Puka Nacua has finished among the top 20 weekly receivers in six of his seven games since returning to the Los Angeles Rams after suffering an injury. He’s also coming off his best game of the year, setting season highs with 17 touches on 19 targets for 178 yards from scrimmage and two total touchdowns against the Buffalo Bills. His consistent production and positive drive make him one of the best overall wide receivers for this week’s lineups.
must begin
- Kyren Williams
- Puka Nacua
- Cooper Kupp
- George Kittle
DFS Picks
- Brock Purdy
- Matthew Stafford
- John Jennings
Week 15 49ers vs Rams TNF Fantasy Football Sit ‘Em Picks
Deebo Samuel has been unusually unproductive in fantasy football recently. He has failed to surpass 25 receiving yards in each of his last four games and has gone without a touchdown for eight consecutive weeks. The 49ers have been using their other offensive weapons much more than Samuel, making him a clear fade in Week 15 lineups, especially with the fantasy playoffs beginning this week in most leagues.
He’s joined by Blake Corum, who has yet to establish a big enough role with the Rams to provide much fantasy value. The rookie has received eight carries in each of his last two games, matching his season high, but has yet to finish inside the top 40 rushers in any of his games so far. He simply can’t be relied on in fantasy lineups unless his role increases down the stretch.
must sit
- Blake Corum
- Samuel Deebo
- Colby Parkinson
- DeMarcus Robinson
DFS fades
- Isaac Guerendo
- Patrick Taylor
- Samuel Deebo
Edited by Nadim El Kak.